抑癌基因p16编码的基因产物通过与细胞周期蛋白依赖性激酶(CDK)结合而抑制细胞周期素的活性,阻止细胞于G_G/S用期。p16基因的失活与肿瘤的发生、发展有密切关系。本文从分子水平初步探讨了该基因在口腔鳞癌中改变情况及与临床病理资料的关系。 方法 对48例口腔鳞癌和相应正常组织的DNA样本进行缺失分析和单链构像多态性分析,研究pl6基因的缺失和第一、二外显子的突变情况。 The gene product encoded by the tumor suppressor gene p16 inhibits cyclin activity by binding to cyclin-dependent kinases (CDKs), preventing cells from G_G / S expiration. Inactivation of p16 gene is closely related to tumorigenesis and development. In this paper, the molecular level of the gene in oral squamous cell carcinoma of the change and its relationship with clinicopathological data. Methods DNA samples from 48 patients with squamous cell carcinoma of the oral cavity and corresponding normal tissues were analyzed for deletion and single-stranded conformation polymorphism. The deletion of pl6 gene and the mutation of exon 1 and exon 2 were studied.