近日节律是生物界普遍存在的一种生理现象,而内源性生物钟是产生近日节律的物质基础,它能使生物体感知并适应环境中的光、温度和食物等周期信号,从而使生物体与外界环境保持周期同步。研究表明,葡萄糖、胆固醇、腺苷、咖啡因、维生素A和视黄酸等营养物质能通过各自不同的方式调控哺乳动物的生物钟,影响其近日节律的信号输出。本文概述了至今为止研究发现的各类与生物钟信号调控相关的营养物质及功能的相关研究进展。 Recent rhythm is a common physiological phenomenon in the biological world, and the endogenous circadian clock is the material basis for the recent rhythm, which enables organisms to sense and adapt to the environment of light, temperature and food cycle signals, so that organisms With the external environment to maintain cycle synchronization. Studies have shown that nutrients such as glucose, cholesterol, adenosine, caffeine, vitamin A and retinoic acid can regulate the mammalian circadian clock in different ways, affecting the signal output of recent rhythms. This article summarizes the research progress of various types of nutrients and functions related to the regulation of circadian clock discovered to date.