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目的 探讨 40岁以下妇女上皮性卵巢癌的临床、病理特点及其预后。方法 对 1990年～ 1997年收治的 198例上皮性卵巢癌患者 ,按年龄分为研究组 ( <40岁 ,44例 )及对照组 ( >40岁 ,15 4例 ) ,对 2组的临床病理资料进行统计分析。结果 研究组与对照组的 2年生存率分别为 75 .6%、5 4.3 % ,5年生存率分别为 5 7.1%、3 8.5 % ,2组有显著性差异 (P >0 .0 5 )。对 2组的临床及病理特点的研究发现 :研究组中临床Ⅰ期、粘液性腺癌及病理学分级低的病例所占比例均比对照组高 ,CA12 5值高于 65U /ml的病例数明显少于对照组 (P均 <0 .0 5 )。 2组均行手术治疗及化疗 ,其残留癌灶大小及化疗疗程均无明显差异。结论 年龄是影响上皮性卵巢癌预后的因素之一 ,判断其预后应结合临床分期、病理类型及组织分级进行综合考虑 ,治疗前CA12 5值高于 65U /ml的患者预后不良。
Objective To investigate the clinical and pathological features and prognosis of epithelial ovarian cancer in women under 40 years of age. Methods A total of 198 patients with epithelial ovarian cancer who were admitted from 1990 to 1997 were divided into study group (<40 years old and 44 cases) and control group (> 40 years old and 154 cases) according to age. The clinical pathology Data for statistical analysis. Results The 2-year survival rates of the study group and the control group were 75.6% and 53.3%, respectively. The 5-year survival rates were 51.1% and 8.5% respectively. There was significant difference between the two groups (P> 0.05) . The two groups of clinical and pathological features of the study found that: the clinical group Ⅰ, mucinous adenocarcinoma and pathological grade lower proportion of cases were higher than the control group, CA12 5 value higher than 65U / ml of the number of cases was significantly Less than the control group (all P <0.05). There were no significant differences between the two groups in the surgical treatment and chemotherapy, the size of the residual tumor and the course of chemotherapy. Conclusion Age is one of the factors affecting the prognosis of epithelial ovarian cancer. The prognosis should be considered in combination with clinical stage, pathological type and histological grade. The prognosis of patients with CA12 5 higher than 65 U / ml before treatment is poor prognosis.