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目的：探讨运脾消食颗粒对厌食症大鼠模型胃泌素(gastrin)﹑锌(Zn)含量的影响。方法采用病因模拟法建立小儿厌食症动物模型﹐分别对模型大鼠摄食量﹑体重以及gastrin﹑Zn含量进行检测。结果运脾消食颗粒可以明显增强厌食症大鼠的食欲﹐增加体重﹐提高胃窦部gastrin和血清Zn含量﹐与模型对照组比较﹐差异均有统计学意义(<0.05或<0.01)。结论运脾消食颗粒对厌食症模型具有明显治疗作用。其发挥临床疗效的作用机制可能是通过调节gastrin﹑Zn含量实现的。“,”Objective To study the Yunpixiaoshi particles on rats model of anorexia gastrin and zinc levels. Methods The etiology simulation method is adopted to establish the animal model of infantile anorexia in food intake, weight of model rats and gastrin and zinc content in the test. Results Yunpixiaoshi particles can significantly enhance the appetite of anorexia rats, weight gain, increase the gastrin of gastric antrum and serum zinc content, compared with model control group, the difference had statistical significance ( <0.05or <0.01).Conclusion Yunpixiaoshi particles on anorexia model has obvious therapeutic effect. The play to the role of the clinical curative effect mechanism may be through regulating gastrin and zinc content in the implementation.