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目的 了解大肠癌患者粪胆汁酸代谢状况 ,探讨粪胆汁酸与大肠癌发生的关联性。方法 应用薄层层析色谱法测定大肠癌患者及正常对照人群粪中胆酸 ,鹅脱氧胆酸 ,脱氧胆酸 ,石胆酸的浓度。结果 大肠癌患者粪总胆汁酸及次级胆汗酸 (脱氧胆酸 ,石胆酸 )浓度以及次级胆汁酸 /初级胆汁酸、脱氧胆酸 /胆酸、石胆酸 /脱氧胆酸等指标明显高于正常对照组。而初级胆汁酸 (胆酸 ,鹅脱氧胆酸 )两组间无统计学差异。结论 粪胆汁酸浓度尤其是次级胆汁酸浓度增高可能是大肠癌促发因素之一。
Objective To understand the status of fecal bile acid metabolism in patients with colorectal cancer and to investigate the association between fecal bile acid and colorectal cancer. Methods TLC was used to determine the concentrations of bile acid, chenodeoxycholic acid, deoxycholic acid, and lithocholic acid in feces of patients with colorectal cancer and normal controls. Results Concentrations of fecal total bile acids, secondary bile acids (deoxycholic acid, lithocholic acid), secondary bile acids/primary bile acids, deoxycholic acid/cholic acid, lithocholic acid/deoxycholic acid and other indicators in patients with colorectal cancer Significantly higher than the normal control group. The primary bile acids (cholic acid, chenodeoxycholic acid) were not statistically different between the two groups. Conclusion The increase of fecal bile acid concentration, especially the increase of secondary bile acid concentration, may be one of the factors that promote colon cancer.