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目的:考察清开灵与氧氟沙星氯化钠注射液配伍对清开灵中尿苷、鸟苷和(R,S)-告依春含量的影响。方法:采用HPLC法测定清开灵注射液中尿苷、鸟苷和(R,S)-告依春的含量,考察清开灵与氧氟沙星氯化钠注射液配伍溶液在25℃恒温水浴下放置9 h,溶液pH、颜色和成分含量的变化。结果:清开灵注射液中尿苷、鸟苷和(R,S)-告依春含量分别为26.4、42.6和50.2μg/mL。配伍溶液在25℃恒温水浴下放置9 h,溶液pH、颜色(棕黄色澄明液体)和尿苷、鸟苷、(R,S)-告依春的含量没有显著变化。结论:清开灵与氧氟沙星氯化钠注射液25℃下放置9h稳定。
Objective: To investigate the effects of Qingkailing and ofloxacin sodium chloride injection on Qingkailing uridine, guanosine and (R, S) - reported by spring content. Methods: The contents of uridine, guanosine and (R, S) - Yichun in Qingkailing Injection were determined by HPLC. The compatibility of Qingkailing with ofloxacin sodium chloride injection solution was determined at 25 ℃ Under water bath for 9 h, the pH, color and composition of the solution were changed. Results: The concentrations of uridine, guanosine and (R, S) -induced spring in Qingkailing injection were 26.4, 42.6 and 50.2μg / mL, respectively. The compatibility of the solution at 25 ℃ water bath for 9 h, pH, color (brown clear liquid) and uridine, guanosine, (R, S) - reported Yichun content did not change significantly. Conclusion: Qingkailing and ofloxacin sodium chloride injection at 25 ℃ 9h stable.