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有机氟化物由于其特殊的性质被广泛应用于医药、农药以及材料领域中,然而由于氟元素的强电负性使得引入氟原子充满了挑战.过渡金属催化的碳氢键氟化反应由于其避免了使用预官能化的底物,而且对自然界中最广泛存在的碳氢键进行直接活化官能化,因此与传统的过渡金属催化的偶联反应相比在原子经济性、反应多样性以及环境友好性等方面都具有突出的优势.近十年来,利用过渡金属催化碳氢键氟化策略已经成为构建碳氟键重要手段和研究热点.作者较全面地综述近年来过渡金属催化的碳氟键构建的研究进展及合成应用,对该领域所存在的问题和局限性进行了总结,并对今后的发展做了展望.
Due to their special properties, organic fluorides are widely used in the fields of medicine, pesticides and materials, however, the introduction of fluorine atoms due to the strong electronegativity of fluorine elements poses a challenge. Transition metal-catalyzed carbon-hydrogen bond fluorination due to its avoidance The use of pre-functionalized substrates, as well as the direct activation of the most widely existing carbon-hydrogen bonds in nature, has led to the development of a new transition metal-catalyzed coupling reaction that is less costly than conventional transition metal-catalyzed coupling reactions in terms of atomic economy, Etc. In recent ten years, the use of transition metal-catalyzed carbon-hydrogen bond fluorination strategy has become an important means and research hotspot in the construction of carbon-fluorine bond.The author reviewed the transition metal-catalyzed carbon-fluorine bond construction in recent years Research progress and synthesis of applications, the problems and limitations in this area are summarized, and the future development prospects.