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目的:探讨茵栀黄注射液及腺苷蛋氨酸治疗极低出生体重儿胃肠外营养相关性胆汁淤积症(PNAC)的效果。方法:将60例PNAC患儿随机分成两组,治疗Ⅰ组予常规治疗+胃肠外营养+茵栀黄注射液,治疗Ⅱ组予常规治疗+胃肠外营养+腺苷蛋氨酸。结果:治疗Ⅰ组及治疗Ⅱ组均能降低PNAC患儿的总胆红素、直接胆红素。在降脂方面,治疗Ⅰ组降低甘油三酯有统计学意义,治疗Ⅱ组在降脂方面治疗无统计学意义。结论:中西医治疗极低出生体重儿胃肠外营养相关性胆汁淤积症均能有效降低直接胆红素水平,菌栀黄注射液能降低血脂水平。
Objective: To investigate the effect of Yinzhihuang Injection and adenosylmethionine in the treatment of parenteral nutrition-associated cholestasis (PNAC) in very low birth weight infants. Methods: Sixty children with PNAC were randomly divided into two groups. The patients in group Ⅰ received conventional therapy plus parenteral nutrition plus Yinzhihuang injection. The patients in group Ⅱ received routine therapy plus parenteral nutrition plus adenosylmethionine. Results: Treatment Ⅰ and Ⅱ could reduce total bilirubin and direct bilirubin in children with PNAC. In lipid-lowering, the treatment group Ⅰ reduced triglyceride was statistically significant, the treatment group Ⅱ in lipid-lowering treatment was not statistically significant. Conclusion: Both TCM and WM treatment of parenteral nutrition-related cholestasis in very low birth weight infants can effectively reduce the level of direct bilirubin, and Zhizhi Huang injection can reduce the level of blood lipid.