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中国的东南部是全球鼻咽癌高发区域之一,对鼻咽癌转移机制的研究存在强烈的需求。凭借可视化光子技术研究鼻咽癌转移机制与LMP-1癌蛋白的关联性,探索早期预测癌转移的潜在可能并进行调控干预,提高患者的生存率,具有医学理论意义和临床应用价值。本文综述了近年来相关研究的发展趋势,特别是高分辨光学成像技术与荧光相关光谱技术的新进展。展望了以鼻咽癌细胞调控的LMP-1为特异性靶标,结合高灵敏度分子荧光探针技术,获取癌细胞脂筏微区的高分辨光学成像和LMP-1动态聚集特性的光学表征,达到可视化且半定量地预测鼻咽癌转移的倾向,为有效地提高鼻咽癌患者治愈率提供新思路和理论支持。
The southeastern part of China is one of the high incidence areas of nasopharyngeal carcinoma in the world. There is a strong demand for the study of the metastasis mechanism of nasopharyngeal carcinoma. With the help of visual photon technique to study the correlation between NPC metastasis mechanism and LMP-1 oncoprotein, to explore the potential of early prediction of cancer metastasis and to control the intervention and improve the survival rate of patients, it has the medical theory significance and clinical application value. In this paper, the development trend of related research in recent years is reviewed, especially the new development of high resolution optical imaging and fluorescence correlation spectroscopy. The LMP-1 targeting to nasopharyngeal carcinoma cells is expected to be a specific target. Combined with high-sensitivity molecular fluorescence probe technology, the optical characterization of high resolution optical imaging and dynamic aggregation of LMP-1 in lipid rafts of cancer cells is obtained. Visualization and semi-quantitative prediction of nasopharyngeal carcinoma metastasis tendency, to effectively improve the cure rate of nasopharyngeal carcinoma patients with new ideas and theoretical support.