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目的：探讨脑脉舒宁降压作用的机理。方法：采用大鼠胸主动脉条测定脑脉舒宁对去甲肾上腺素（ＮＥ）、ＣａＣｌ２的量效曲线以及对单剂量氯化钾所致收缩的影响。结果：脑脉舒宁能使ＮＥ、ＣａＣｌ２的量效曲线右移，最大反应压低，呈非竞争性拮抗；同时也可抑制高钾去极化引起的血管条收缩。结论：脑脉舒宁松弛血管平滑肌的作用与拮抗Ｃａ２＋有关。
Objective: To explore the mechanism of antihypertensive effect of Naomaisin. Methods: The effect of Naomaisuning on NE and CaCl2 and the effect of single dose potassium chloride on contractility induced by single dose of potassium chloride were determined by rat thoracic aortic strips. Results: Cerebrospinal fluid Shuining can shift the dose-effect curve of NE and CaCl2 to the right, the maximum response pressure is low, showing noncompetitive antagonism; at the same time, it can also inhibit the contraction of vascular strips induced by high potassium depolarization. Conclusion: The effect of brain smooth muscle relaxant on vascular smooth muscle is antagonistic to Ca2 +.