麦迪霉素(midecamycin)为大环内酯类抗生素。该药物在pH2以下不稳定,胃中极易被破坏,且有胃肠道不良反应,所以,临床上常用肠溶片和肠溶胶囊。鉴于该药为难溶性药物,吸收受剂型因素影响,为控制和提高药品质量,作者在系统研究麦迪霉素肠溶片溶出度和 Midecamycin is a macrolide antibiotic. The drug instability in the pH2 below, the stomach can easily be destroyed, and gastrointestinal adverse reactions, therefore, commonly used in clinical enteric-coated tablets and enteric-coated capsules. In view of the drug as a poorly soluble drug, absorbed by the dosage form factors, in order to control and improve the quality of medicines, the authors systematically study the dissolution of midecamycin enteric-coated tablets and