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在心力衰竭引起心排出量减低的患者,常通过神经、体液等机理使周围血管阻力增高,以维持动脉压。心力衰竭时肾素-血管紧张素(R-A)系统活性增高。由于血管紧张素是强血管收缩物质,故肾素活性增加在周围血管的收缩中可能起有重要作用。本文报道阻断血管紧张素Ⅰ转化为血管紧张素Ⅱ的转化酶抑制剂Teprotide(SQ20881)对15例慢性严重左心衰竭患者的血液动力学影响,以探讨肾素-血管紧张素系统在慢性心力衰竭时周围血管收缩中的作用。方法:15例慢性充血性心力衰竭患者,血压正常或轻度降低,其中缺血性心脏病7例,心肌病8
In patients with heart failure caused by decreased cardiac output, often through the nerves, body fluids and other mechanisms to increase peripheral vascular resistance to maintain arterial pressure. Heart failure renin - angiotensin (R-A) system activity increased. Since angiotensin is a strong vasoconstrictor substance, increased renin activity may play an important role in the contraction of peripheral blood vessels. This article reports the hemodynamic effects of Teprotide (SQ20881), a transrease inhibitor that blocks the conversion of angiotensin I to angiotensin II, in 15 patients with chronic severe left heart failure to investigate the effects of renin-angiotensin system on chronic heart failure The role of peripheral vasoconstriction in failure. Methods: 15 patients with chronic congestive heart failure, normal or mild blood pressure, including 7 cases of ischemic heart disease, cardiomyopathy 8