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目的研究应用美托洛尔与地尔硫对X综合征患者的疗效。方法收集2005年7月至2006年5月山东省医学科学院附属济宁市第一人民医院诊断的X综合征患者42例,将其随机分为美托洛尔组(20例)和地尔硫组(22例),随访治疗3个月后的临床情况并复查平板运动试验及冠状动脉血流储备(CFR)。结果与用药前相比,用药后2组平板运动试验到达终点时间均明显延长(P<0.05),CFR均明显升高(P<0.05)。临床胸痛及平板运动试验阳性显著减少(P<0.01)。与地尔硫组相比,美托洛尔组平板运动试验中到达运动终点时间显著延长(P<0.05),CFR显著升高(P<0.05)。结论美托洛尔与地尔硫能提高心脏X综合征患者的运动耐量及CFR,美托洛尔较地尔硫更为有效。
Objective To study the effect of metoprolol and diltiazem on patients with syndrome X. Methods Twenty-two patients with X syndrome diagnosed in Jining First People’s Hospital Affiliated to Shandong Academy of Medical Sciences from July 2005 to May 2006 were randomly divided into metoprolol group (n = 20) and diltiazem (N = 22) were followed up for 3 months. The treadmill exercise test and coronary flow reserve (CFR) were also reviewed. Results Compared with those before treatment, the mean time to reach the end of treadmill exercise test was significantly longer (P <0.05) and the CFR were significantly increased (P <0.05). Clinical chest pain and treadmill test were significantly reduced (P <0.01). Compared with diltiazem group, metoprolol group treadmill exercise reached the end of exercise time was significantly longer (P <0.05), CFR significantly increased (P <0.05). Conclusion Metoprolol and diltiazem can improve exercise tolerance and CFR in patients with cardiac syndrome X. Metoprolol is more effective than diltiazem.