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应用核仁组成区嗜银蛋白（ＡｇＮＯＲｓ）染色技术观测了１００例胃良、恶性病变细胞ＡｇＮＯＲｓ含量及形态。结果显示：慢性浅表性胃炎上皮细胞核内ＡｇＮＯＲｓ计数平均为１．４１；慢性萎缩性胃炎为１．５５；慢性胃炎伴上皮不典型增生为２．５９；胃癌为３．５６，组间均数差异有统计学意义（Ｐ＜０．０１）。ＡｇＮＯＲｓ形态分布各组间亦有明显差异。表明ＡｇＮＯＲｓ可作为判断胃上皮细胞增生与分化程度的一项形态定量指标，ＡｇＮＯＲｓ染色技术有助于胃癌及癌前病变的鉴别诊断。
AgNORs staining technique was used to observe the content and morphology of AgNORs in 100 benign and malignant gastric lesion. The results showed that the average number of AgNORs in the nucleus of chronic superficial gastritis epithelial cells was 1.41, that of chronic atrophic gastritis was 1.55, that of chronic gastritis and epithelial dysplasia was 2.59, and that of gastric cancer was 3.56 The difference was statistically significant (P <0.01). AgNORs morphological distribution of each group also have significant differences. AgNORs can be used as a quantitative index to determine the degree of proliferation and differentiation of gastric epithelial cells. AgNORs staining can be helpful in the differential diagnosis between gastric cancer and precancerous lesions.