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应用核仁组成区嗜银蛋白(AgNOR)技术对152例活检胃粘膜标本进行观察研究。结果良性病变AgNoR 计数在1.48至8.31个之间,银颗粒小,多数比较一致;恶性病变在4.62至19.75个之问,银颗粒大,不规则。从浅表性胃炎、萎缩性胃炎和异型增生到腺癌 AgNoR 数目渐增,颗粒体积渐大。尽管良性病变中的部分细胞银颗粒的最高值属于恶性病变中的计数范围之内,但每100个细胞中银颗粒≥4的细胞数在50%以下。提示AgNOR 技术对活检胃粘膜良、恶性病变的诊断和鉴别诊断及了解细胞增生变化的程度,判断细胞的生物学行为,上皮癌变过程与早期癌肿的发现均具有临床病理工作的实用性。
Using AgNOR technology, 152 cases of biopsy gastric mucosa specimens were observed and studied. Results The number of benign lesions with AgNoR was between 1.48 and 8.31. The silver particles were small and most of them were consistent. The malignant lesions were between 4.62 and 19.75, and the silver particles were large and irregular. From superficial gastritis, atrophic gastritis and dysplasia to adenocarcinoma, the number of AgNoRs is increasing and the volume of particles is getting larger. Although the highest value of silver particles in some cells in benign lesions falls within the count range in malignant lesions, the number of cells with silver particles ≥ 4 per 100 cells is below 50%. It is suggested that the AgNOR technique is useful for the diagnosis and differential diagnosis of benign and malignant lesions of the gastric mucosa, the degree of changes in cell proliferation, and the biological behavior of the cells. Both the epithelial carcinogenesis process and the early detection of cancers have practical clinical pathological work.