【摘 要】
：
The suprachiasmatic nucleus and Alzheimer\'s disease (AD): AD is the most frequently diagnosed form of dementia, with the total number of AD patients worldwide expected to triple by 2050 compared to 2015 (Prince et al., 2015). Despite years of research,
【机 构】
：
Leiden Institute of Chemistry,Leiden University,Leiden,The Netherlands;Leiden Institute of Chemistry
论文部分内容阅读
The suprachiasmatic nucleus and Alzheimer\'s disease (AD): AD is the most frequently diagnosed form of dementia, with the total number of AD patients worldwide expected to triple by 2050 compared to 2015 (Prince et al., 2015). Despite years of research, much of the AD pathology remains unclear with no treatment or cure available. Besides its two hallmarks, amyloid-β (Aβ) plagues and hyperphosphorylated tau tangles, a distortion of circadian rhythms is commonly observed. Furthermore, poor sleep quality or trouble falling asleep are common AD symptoms, sometimes developing 10–15 years before cognitive symptoms associated with AD (Ju et al., 2014).
其他文献
Intracerebral hemorrhage (ICH) is a subtype of stroke associated with higher rates of mortality. Currently, no effective drug treatment is available for ICH. The molecular pathways following ICH are complicated and diverse. Nucleic acid therapeutics such
Epigenetic mechanisms regulate the chromatin structure and gene expression levels without changing the primary DNA sequence, and include DNA methylation and hydroxymethylation, post-translational modifications of histone tails and nucleosome positioning,
Cerebral focal ischemic stroke (FIS) is a leading brain disorder associated with human debilitation and death. It is induced by the formation of a thrombus in the arteries that supply blood to the central nervous system. FIS patients may suddenly experien
Parkinson\'s disease (PD) is a movement disorder characterized by reduced dopamine levels due to degeneration of the substantia nigra. The clinical presentation is underlined by bradykinesia, postural instability, and tremors. PD is the second most comm
Traumatic brain injury (TBI) is a major cause of morbidity and mortality worldwide. Despite significant medical advances over recent decades, many survivors of TBI develop long term neuro-cognitive deficits. Previously, only moderate and severe injuries w
Flow cytometry is a versatile technique for analyzing stroke-induced changes in the immune system. Unlike other methods of cell identification such as immunohistochemistry, the technique is rapid, highly sensitive, and capable of quantifying multiple mark
石英光纤作为常见的一种传能光纤,在高能激光照射条件下易产生损伤,从而影响整个光学系统的传输效率。在造成激光诱导光纤损伤的机理中,光纤热效应造成的损伤极易对光纤系统造成影响。目前,使用有限元法对石英光纤热效应和损伤性质的研究较少,本文通过使用有限元方法,在高纯石英光纤模型中研究了千瓦级激光引起的热损伤。通过模拟计算研究了光纤损耗,热吸收和熔融损伤。利用有限元方法,在高纯石英光纤模型中研究了高能激光引
Primary open-angle glaucoma as a causal factor for circadian disruption: Living by the clock, in alignment with external time cues is an important condition for human health and well-being. Periodic changes in the ambient light serve as a key factor to sy
Vascular leakage and angiogenesis in diseases: The vascular system carries blood throughout the body to supply oxygen and nutrients to tissues and remove waste from tissues. Dysfunction of the vascular system worsens many diseases. In this perspective, va
Some scholars have recently developed the concept of PANoptosis in the study of infectious diseases where pyroptosis, apoptosis and necroptosis act in consort in a multimeric protein complex, PANoptosome. This allows all the components of PANoptosis to be