【摘 要】
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Vascular leakage and angiogenesis in diseases: The vascular system carries blood throughout the body to supply oxygen and nutrients to tissues and remove waste from tissues. Dysfunction of the vascular system worsens many diseases. In this perspective, va
【机 构】
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Department of Pharmacology and Regenerative Medicine,Department of Ophthalmology and Visual Sciences
论文部分内容阅读
Vascular leakage and angiogenesis in diseases: The vascular system carries blood throughout the body to supply oxygen and nutrients to tissues and remove waste from tissues. Dysfunction of the vascular system worsens many diseases. In this perspective, vascular function in blinding eye diseases, current therapies, and our developing approach will be introduced.rnThe blood vessels are composed of the monolayer of the endothelial cells, and the outer layer made by pericytes and smooth muscle cells provide structural support and shape to the vessel. Endothelial monolayers function as a barrier. The barrier function of endothelial monolayers controls plasma protein uptake and the infiltration of immune cells by regulating adherence of cell-cell junction. Vascular leakage causes unwanted plasma leak, accumulation of immune cells, and tissue inflammation.
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