论文部分内容阅读
以大鼠肝微粒体为代谢模型,对沙蚕毒素类杀虫剂-易卫杀(N N-二甲基-1,2,3-三噻烷-5-胺草酸盐)进行了体外代谢观察,结果表明易卫杀经大鼠肝微粒体的代谢速率较快,其主要代谢产物有N,N-二甲基-1,2-二硫环戊烷-4胺(a,沙蚕毒素);N,N-二甲基-1,3双(甲亚磺酰基)-2-丙胺(b);N-甲基-1,2-二硫环戊烷-4-胺(c);硫磺聚合物(d)及甲基氨基丙烷(f),可能的代谢途径为:易卫杀脱掉一个硫原子变成沙蚕毒素;沙蚕毒素脱甲基生成脱甲基产物;沙蚕毒素甲基化后进一步生成N,N-二甲基-1,3-双(甲亚磺酰基)-2-丙胺。
The rat liver microsomes were used as metabolic models for the nereistoxin-based insecticide-N-dimethyl-1,2,3-trithien-5-amine oxalate Metabolic observation showed that the metabolic rate of easy-to-kill rat liver microsomes was faster and its main metabolites were N, N-dimethyl-1,2-dithiolane-4-amine Toxin); N, N-dimethyl-1,3 bis (methanesulfinyl) -2-propanamine (b); N-methyl-1,2-dithiolan-4- ; Sulfur polymer (d) and methylaminopropane (f), the possible metabolic pathways: easy to kill off a sulfur atom into Nereis toxin; nereistoxin demethylation demethylation products; Nereis Methylation of the toxin further yields N, N-dimethyl-1,3-bis (methylsulfinyl) -2-propanamine.