论文部分内容阅读
用抗血小板血清耗竭致敏大鼠血小板后可明显抑制卵白蛋白诱发的过敏性休克。接受致敏大鼠血小板输注后的非致敏大鼠可在卵白蛋白攻击后产生明显的血压下降，血小板的输注量与血压下降程度呈正比，在体外，卵白蛋白可诱发致敏大鼠血小板产生化学发光，但无明显的５－羟色胺释放；反之，经典的血小板活化剂凝血酶。血小板活化因子或二磷酸腺苷在引起致敏大鼠血小板释放５－羟色胺的同时不产生明显的化学发光。电镜观察发现，在抗原攻击下只有致敏大鼠血小板能发生活化改变。这一现象有力证明血小板在速发型变态反应中的作用是通过抗原特异性机制所介导。阿魏酸钠不仅可抑制抗原诱发的过敏性休克。而且能抑制抗原诱发的血小板活化，提示其抗变态反应作用与其抑制血小板功能密切相关．
Anaphylactic shock induced by ovalbumin can be significantly inhibited by sensitized rat platelets after anti-platelet depletion. Non-sensitized rats receiving sensitized rat platelet transfusions developed a significant decrease in blood pressure after challenge with ovalbumin, and the amount of platelet transfusions was proportional to the decrease in blood pressure. In vitro, ovalbumin sensitized rats Platelets produce chemiluminescence, but no significant serotonin release; conversely, the classic platelet activator thrombin. Platelet-activating factor or adenosine diphosphate does not produce significant chemiluminescence upon the release of serotonin from sensitized rat platelets. Electron microscopy showed that only the sensitized rat platelets under the attack of antigen can undergo activation changes. This phenomenon strongly supports the role of platelets in rapid-onset allergic reactions mediated by antigen-specific mechanisms. Sodium ferulate not only inhibits antigen-induced anaphylactic shock. But also inhibit antigen-induced platelet activation, suggesting that its anti-allergic effects and its inhibition of platelet function are closely related.