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目的快速鉴别依巴斯汀药品是否发生光照变质或过期变质,并理解光照变质的机制。方法分别检测未变质、被太阳光及不同波长激光照射后依巴斯汀的拉曼光谱,分析并利用依巴斯汀在400 cm-1~1 800 cm-1光谱内的变化来快速鉴别药品是否发生了光照变质或过期变质,并进一步讨论分析药品发生变质的变化过程。结果对比未经光照的依巴斯汀,无论是太阳光还是激光照射后的依巴斯汀,其拉曼光谱都有非常明显的改变,且都可以用激光拉曼光谱仪快速检测。结论拉曼光谱法可以用于快速鉴别依巴斯汀是否发生光照变质,光照变质是由于依巴斯汀分子中C9-N键和C7-C6-O键很容易发生改变而生成二苯甲醇而且太阳光照射后的依巴斯汀有黄色荧光效应,其主要是由太阳光中能量较高的蓝光或紫外光照射产生的。
OBJECTIVE Rapid identification of ebastine drug whether photodegradation or expiration metamorphosis, and understand the mechanism of light deterioration. Methods Raman spectra of ebastine after non-metamorphic, sun-light and laser of different wavelengths were detected, and the changes of ebastine in 400 cm-1 ~ 1800 cm-1 spectra were analyzed and quickly identified Whether the occurrence of light deterioration or expiration of deterioration, and further discussion of changes in the process of deterioration of drugs. Results Compared with non-irradiated ebastine, the ebastine after either sunlight or laser irradiation had a very significant change in its Raman spectrum, and both could be rapidly detected by laser Raman spectroscopy. Conclusions Raman spectroscopy can be used to quickly identify whether ebastine photodegradation occurs or not. Light deterioration is due to the fact that the C9-N bond and C7-C6-O bond in ebastine molecule are easily changed to produce benzhydrol and Ebastine after irradiation with the sun has a yellow fluorescence effect, which is mainly caused by high energy blue light or ultraviolet light in the sunlight.