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以往的研究表明,大黄牡丹皮汤能防止缺血再灌注损伤引起的肾衰。缺血再灌注主要损伤肾近曲小管,先锋霉素Ⅱ是一种选择性地损害肾近曲小管的药物,因此,作者研究了大黄牡丹皮汤对先锋霉素Ⅱ诱导的肾损害的影响。 全方提取物及各生药提取物参照小太郎汉方制药株式会社的标准制备。Wistar大鼠分为5组,分别给予水、大黄牡丹皮汤、大黄、牡丹皮或桃仁,各药物剂量为200mg/kg体
Previous studies have shown that rhubarb peony bark soup can prevent renal failure caused by ischemia-reperfusion injury. Ischemia-reperfusion mainly damages the renal proximal tubules. Pioneermycin II is a drug that selectively damages the renal proximal tubules. Therefore, the authors studied the effect of Dahuang Mudanpi Decoction on the kidney injury induced by cephalosporin II. All extracts and various crude drug extracts were prepared according to the standard of Kotaro Okaharu Pharmaceutical Co., Ltd. Wistar rats were divided into 5 groups and given water, rhubarb peony bark soup, rhubarb, moutan bark or peach kernel respectively. The dose of each drug was 200 mg/kg body weight.