疾病的空间聚集性(spatial clustering)是指疾病的发生在空间上表现出的聚集倾向或趋势及疾病的空间分布特点和规律~([1])。近年来,在流行病学研究领域,空间信息技术已逐步应用于疾病的空间聚集性研究。其中,Sa TScan,即圆形扫描法在传染病研究中应用多于其他软件~([2])。2008年,Takahashi等~([3])提出了适宜于监测不规则区域疾病暴发的时空扫描统计方法,即Fle XScan。手足口病是由肠道 Spatial clustering of the disease refers to the spatial tendency and trend of the disease occurring in the space and the spatial distribution characteristics and rules of the disease ~ ([1]). In recent years, in the field of epidemiology, spatial information technology has been gradually applied to the study of spatial agglomeration of diseases. Among them, Sa TScan, the circular scanning method, has more applications in infectious disease research than any other software ([2]). In 2008, Takahashi et al. ([3]) proposed a spatio-temporal scanning statistical method suitable for monitoring outbreaks of irregular areas, namely Fle XScan. Hand, foot and mouth disease is by the intestine