1933年Flosdorf采用冻干方法制出了干燥人血清及血浆并用于预防和治疗。随着治疗血清精制方法的改进和使用要求,已广泛使用冻干方法制备干燥血清和各种免疫球蛋白。而采用盐析法制备的免疫球蛋白冻干后难溶,通常需30分钟以上(蛋白含量8％以上),且外观结晶粗糙。为了加快冻干球蛋白的溶解速度,参考日本安达秀雄的报导,在冻干前添用氨基酸和醣类作为保护剂 In 1933 Flosdorf lyophilized to dry human serum and plasma for prevention and treatment. With the refinement and use of therapeutic serum purification methods, lyophilization methods have been widely used to prepare dry serum and various immunoglobulins. The immunoglobulin prepared by salting-out method is freeze-dried and insoluble, usually takes more than 30 minutes (the protein content is more than 8%), and the appearance is rough. In order to speed up the lyophilization of globulin, reference to the Japanese Anda Hidehiro, amino acids and sugars were added as preservatives before lyophilization