目前,筛选抗炎症药物多以各种致炎物(如角叉菜胶、甲醛,鸡蛋清和右旋糖酐等)所致的大鼠足肿胀为炎症模型。如果所试药物对正常大鼠的足肿胀具有抑制作用,而对去肾上腺大鼠无抗炎作用,则习惯地认为该药的抗炎作用是由于刺激肾上腺皮质激素分泌所致。我们认为,这个结论只有在药物本身不具有应激刺激的情况下才是正确的。当由于所试药物 Currently, many anti-inflammatory drugs are screened for inflammation of the paw in rats due to various inflammatory substances such as carrageenan, formaldehyde, egg white and dextran. If the tested drug has an inhibitory effect on foot swelling in normal rats and no anti-inflammatory effect on adrenal rats, it is customarily considered that the anti-inflammatory action of the drug is due to the stimulation of adrenocorticotropic hormone secretion. In our opinion, this conclusion is correct only if the drug itself does not have stress stimuli. When due to the drug tested