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硫代硫 钠是氰化物的解毒剂。尚有抗过敏及镇静作用。临床上主要用于氰化物中毒、皮肤瘙痒症,慢性荨麻疹等疾病。我院用硫代硫酸钠治疗链霉素不良反应10例,疗效显著,现将用药情况报告如下: 临床资料 一般资料:10例男性Ⅱ型肺结核患者,年龄在28～45岁,均为初治病例。痰菌为阴性,均在强化治疗阶段(方案为2HSZ~(1),)用链霉素0.75g肌注,每日一次。10例患者用链霉素第三天。均出现轻度头晕、口唇麻木,耳鸣。即用士的宁1mg肌注。一日一次,以对抗链霉素的副作用(链霉素继续应用)。用药第五天,10例患者诉上述症状加重,其中3例出现头痛,皮肤瘙痒、恶心感。停用士的宁,改用硫代硫酸钠。
Sodium thiosulfate is a cyanide antidote. There are anti-allergic and sedative effects. Clinically used mainly for cyanide poisoning, pruritus, chronic urticaria and other diseases. In our hospital with sodium thiosulfate treatment of streptomycin adverse reactions in 10 cases, the effect is significant, the medication is now reported as follows: Clinical data General information: 10 cases of male patients with type Ⅱ tuberculosis, aged 28 to 45 years, are naïve Case. Sputum bacteria were negative, are in the intensive treatment phase (scheme 2HSZ ~ (1), streptomycin 0.75g intramuscular injection, once daily. 10 patients with streptomycin on the third day. Have mild dizziness, numb lips, tinnitus. That is to use the mint 1mg intramuscular injection. Once a day to fight streptomycin side effects (streptomycin continues to be used). On the fifth day of treatment, 10 patients complained of the above symptoms, including 3 cases of headache, pruritus and nausea. Disable strychnine, use sodium thiosulfate instead.