近年来,杯芳烃已成为仿生领域中倍受关注的一类仿酶模型主体。鉴于它具有与环糊精类似的疏水空穴,同时又表现出构象多重性,在对底物分子实施包络作用时,随化学环境变化,其构象会发生相应的改变,因此,作为仿酶模型的结合部位更接近天然酶。我们首次设计并合成了以杯芳烃为结合部位,金属卟啉为催化部位的仿P-450单加氧酶模型,其合成路线如下: In recent years, calixarenes have become a kind of imitation enzyme model body which has attracted much attention in the field of bionics. In view of its hydrophobic hole similar to cyclodextrin and the conformational multiplicity at the same time, its conformation will change correspondingly with the change of chemical environment when enveloping substrate molecules. Therefore, The model’s binding site is closer to the native enzyme. We first designed and synthesized a pseudo-P-450 monooxygenase model with calixarene as the binding site and metalloporphyrin as the catalytic site. The synthetic route is as follows: