钙离子是具有多种生物学功能的离子,起着极为重要和广泛的生理作用。有越来越多的资料表明Ca_(2+)参与疼痛调控过程,如吗啡的中枢镇痛作用及耐受性的产生都与Ca_(2+)有关。这方面的研究工作已有多篇综述介绍,这里不再重复。本文就Ca_(2+)与外周疼痛调控、内源性疼痛有关的物质及中药中镇痛剂的关系作一介绍,为新镇痛药研究提供一些线索。 Calcium ions are ions with a variety of biological functions and play an extremely important and extensive physiological role. More and more data indicate that Ca2 + participates in the process of pain regulation, such as central analgesia and tolerance of morphine are related to Ca2 +. There have been many reviews in this area and will not be repeated here. This article describes the relationship between Ca 2+ and peripheral pain control, endogenous pain-related substances and analgesics in traditional Chinese medicine, and provides some clues for the study of new analgesics.