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红斑狼疮是一种与自然免疫有关的结缔组织病,临床表现复杂多样,可累及人体大多数器官和组织。病程可有自然缓解和发作相交替,如不及时诊断与正确处理,预后往往严重。近年来由于对本病警惕性的提高和诊断技术的改进,发病率有增高趋势。且本病好发于生育年龄的妇女和可能合并妊娠,故是一个与产科有关的疾病。为了进一步了解妊娠与红斑狼疮之间的关系,特回顾分析了27年期间我院红斑狼疮病人合并妊娠的情况和结果。资料和方法我院从1957年1月到1984年12月,27年中共有23例红斑狼疮病人,在我院24次分娩。这些病人均符合红斑狼疮之诊断标准:①有皮肤病变或合并内脏损害,或虽无皮肤病变,但有多脏器损害,红斑狼疮细胞检查阳性和抗核抗体阳性者。②多脏器损害基本符合美国风湿病协会诊断,在14项临床表现中有4项以上阳性者。这些病人凡出现症状需用药物者,属处于红斑狼疮活动期;凡临床症状缓解无需药物治疗者,属处于红斑狼疮缓解期;而原处于缓解期由于妊娠或分娩出现症状需用药物治疗以及原处于活动期在妊娠或产后虽
Lupus erythematosus is a connective tissue disease associated with innate immunity. Its clinical manifestations are complex and diverse and can affect most organs and tissues of the human body. Course of disease may have natural relief and seizures alternate, if not timely diagnosis and correct treatment, the prognosis is often serious. In recent years due to the increased vigilance of this disease and the improvement of diagnostic techniques, the incidence has increased. And the disease occurs in women of childbearing age and may merge pregnancy, it is a maternity-related disease. In order to further understand the relationship between pregnancy and lupus, especially the retrospective analysis of 27 years of our hospital lupus erythematosus patients with pregnancy and the results. Materials and Methods In our hospital from January 1957 to December 1984, there were 23 cases of lupus erythematosus in 27 years and 24 deliveries in our hospital. These patients are in line with the diagnostic criteria of lupus: ① skin lesions or visceral damage, or although no skin lesions, but there are multiple organ damage, lupus erythematosus cells positive and anti-nuclear antibody positive. ② multiple organ damage basically consistent with the American Society of Rheumatology diagnosis, in 14 clinical manifestations of 4 or more positive. Those patients who have symptoms of medication, are in the active period of lupus; Where the clinical symptoms of remission without medication, is in the lupus remission; and was in remission due to pregnancy or childbirth symptoms need medication and the original In the active phase of pregnancy or postpartum although