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万古霉素是目前临床耐甲氧西林金葡菌感染治疗的一线药物,准确建立和适时调整万古霉素给药方案是临床治疗的关键,针对危重症患者特殊的病理生理状态的个体化治疗尤为重要。本文综述影响危重症患者万古霉素药动学性质的各因素和方案调整。
Vancomycin is currently the first-line drug for clinical methicillin-resistant Staphylococcus aureus infection. Accurately establishing and adjusting vancomycin dosage regimen is the key to clinical treatment. Individualized treatment for special pathophysiological state of critically ill patients is especially important. This article reviews the factors that affect the pharmacokinetic properties of vancomycin in critically ill patients and the program adjustments.