高血脂症是一种常见的心血管类疾病,它会引起动脉粥样硬化,与高血压、冠心病、脑卒中及糖尿病密切相关,从而严重危害人类健康。随着对高血脂症发病机制的深入研究,出现了许多具有新作用机制和新作用靶点的药物,其中二酰基甘油酰基转移酶1(DGAT1)抑制剂受到人们的关注,它主要是通过抑制DGAT1酶的活性来限制甘油三酯的合成。本文简要综述对DGAT1酶具有抑制作用的降血脂药物。 Hyperlipidemia is a common cardiovascular disease, it can cause atherosclerosis, and hypertension, coronary heart disease, stroke and diabetes are closely related, thus seriously endangering human health. With the further study of the pathogenesis of hyperlipidemia, many new drugs with new mechanism of action and new targets have emerged. Diacylglycerol acyltransferase 1 (DGAT1) inhibitors have attracted much attention. It is mainly through inhibition DGAT1 enzyme activity to limit the synthesis of triglycerides. This article briefly reviews lipid-lowering drugs that have an inhibitory effect on DGAT1 enzymes.