论文部分内容阅读
自1987年2月至1989年12月,作者对3例习惯性流产患者,在排除其他原因后,对妻血清中无丈夫白细胞(HLA)抗体者,行皮内注射丈夫淋巴细胞。经过这种免疫治疗后再次妊娠的32例中28例成功,妊娠成功率为87.5%。9对夫妇行 HLA-DR 分型,其中2对夫妇 HLA—DR 有两个位点相同。经免疫治疗后 HLA-DR 抗体阳性率为54.8%,妊娠3～5个月阳性率为63.6%。对7例妊娠成功者进行检测,发现5例有针对丈夫 HLA-特异性抗体的抗独特型抗体。
From February 1987 to December 1989, the author of 3 cases of habitual abortion patients, excluding other causes, the wife of his wife did not have anti-human leukocyte (HLA) antibodies, intradermal injection of her husband’s lymphocytes. Twenty-eight of the 32 patients who had re-immunized after this immunization were successful, with a pregnancy success rate of 87.5%. Nine couples underwent HLA-DR typing, with two couples of HLA-DR having the same two loci. After immunotherapy HLA-DR antibody positive rate was 54.8%, 3 to 5 months of pregnancy positive rate was 63.6%. Seven cases of successful pregnancy were detected and found that 5 cases of anti-idiotypic antibodies against husbands HLA-specific antibodies.