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目的探讨血清肿瘤标志物癌胚抗原(CEA)、CAl9-9、CA72-4和CA242在胃癌术后复发判断中的价值。方法 145例胃癌根治术后患者,术前检测血清CEA、CAl9-9、CA72-4和CA242,术后随访记录复发情况和相关的临床、病理资料,采用Kaplan-Meier法估算无复发生存率,应用Log-rank法进行生存率显著性检验。结果 145例患者中,血清肿瘤标志物CEA、CA19-9、CA242和CA72-4的阳性率分别为35.2%(51例)、29.7%(43例)、24.1%(35例)和36.6%(53例)。在纳入复发分析的118例患者中,有66例(55.9%)复发,52例(44.1%)无瘤生存,无复发中位生存时间为26个月。CA72-4、CAl9-9和CA242阴性患者的无复发生存率显著高于阳性患者。结论肿瘤标志物CA72-4、CAl9-9和CA242阳性可以预测胃癌根治术后的复发情况,这对于筛选高危人群、早期诊治复发和改善患者预后具有重要的临床意义。
Objective To investigate the value of serum tumor markers carcinoembryonic antigen (CEA), CAl9-9, CA72-4 and CA242 in the judgment of postoperative recurrence of gastric cancer. Methods A total of 145 patients with radical resection of gastric cancer were enrolled. Serum CEA, CAl9-9, CA72-4 and CA242 were detected preoperatively. Postoperative recurrence and related clinical and pathological data were recorded. Kaplan-Meier method was used to estimate the recurrence-free survival rate, The Log-rank method was used to test the significance of survival. Results Among the 145 patients, the positive rates of serum tumor markers CEA, CA19-9, CA242 and CA72-4 were 35.2% (51 cases), 29.7% (43 cases), 24.1% (35 cases) and 36.6% 53 cases). Of the 118 patients included in the recurrence analysis, 66 (55.9%) relapsed, 52 (44.1%) had no tumor-free survival and the median recurrence-free survival was 26 months. The recurrence-free survival of CA72-4, CAl9-9 and CA242-negative patients was significantly higher than that of positive patients. Conclusion The positive of tumor markers CA72-4, CA19-9 and CA242 can predict the recurrence of gastric cancer after radical surgery, which has important clinical significance for screening high-risk population, early diagnosis and treatment of recurrence and improve the prognosis of patients.