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炎性关节炎是一组慢性、进展性炎性疾病,能导致关节疼痛和功能障碍,严重影响患者的生活质量。炎性关节炎治疗困难,既往的多种治疗方法存在疗效差,周期长,诱导缓解困难且缓解期短,容易复发,副作用大的问题。近年来生物制剂发展迅速,并广泛应用于炎性关节炎的治疗。生物制剂对许多其他治疗方法无效的病例有良好疗效,且起效迅速,停药后维持缓解期长。其应用标志炎性关节炎的治疗已经进入靶向治疗时代,目前影响其应用的主要问题是可能诱发感染和肿瘤。本文综述了近年研究开发治疗炎性关节炎的生物制剂及其分类、特性和临床应用。
Inflammatory arthritis is a group of chronic, progressive inflammatory diseases that can lead to joint pain and dysfunction, which can seriously affect the patient’s quality of life. Inflammatory arthritis is difficult to treat. Previously, many treatments have poor curative effect, long period, difficult to induce remission, short remission period, easy to relapse and large side effects. In recent years, the rapid development of biological agents, and is widely used in the treatment of inflammatory arthritis. Biologics have been shown to be effective in many cases of ineffective treatment and have shown rapid onset of action with long-term remission after withdrawal. Its application marks the treatment of inflammatory arthritis has entered the era of targeted therapy, the main problem affecting its application is likely to induce infection and cancer. This review summarizes the recent research and development of biological agents for the treatment of inflammatory arthritis, its classification, characteristics and clinical application.