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目的观察不同剂量辛代他汀对患者颈动脉粥样硬化斑块的消退作用及降脂疗效。方法采用彩色多普勒超声技术检出选择颈动脉粥样硬化斑块形成者59例,随机分成两组,分别口服辛伐他汀20mg/d(n=30)、40mg/d(n=29),共24周,观察治疗前后颈动脉内膜中层厚度(IMT)、血总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)的变化。结果口服辛伐他汀20mg/d、40mg/d均能明显消退颈动脉粥样硬化斑块,两组治疗前后比较差异均有统计学意义(P<0.01);降低TC、TG、LDL-C的水平、升高HDL-C的水平,治疗前后差异亦具有统计学意义(P<0.05),辛伐他汀40mg/d较辛伐他汀20mg/d有更强的降脂疗效(P<0.05)。结论辛伐他汀能消退颈动脉粥样硬化斑块,有效安全降低血脂水平。
Objective To observe the subsided effect of carotid atherosclerotic plaque and the effect of lipid-lowering of different doses of statin on patients. Methods Fifty-nine patients with carotid atherosclerotic plaque were detected by color Doppler sonography and divided into two groups randomly. Patients were given simvastatin 20 mg / d (n = 30), 40 mg / d (n = 29) (IMT), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol -C) changes. Results Simvastatin 20 mg / d, 40 mg / d could obviously relieve carotid artery atherosclerotic plaque. The differences between the two groups before and after treatment were statistically significant (P <0.01), and the levels of TC, TG and LDL-C (P <0.05). Simvastatin 40 mg / d had a better lipid-lowering effect than simvastatin 20 mg / d (P <0.05). Conclusion Simvastatin can attenuate carotid artery atherosclerotic plaque and reduce blood lipid levels effectively and safely.