论文部分内容阅读
目的探讨血浆透析滤过治疗全身炎症反应综合征诱发的急性肾损伤的疗效和安全性。方法 15例全身炎症反应综合征诱发的急性肾损伤患者,采用血浆透析滤过治疗,检测治疗前、后肾功能及血清白细胞介素-6、胱抑素C水平,比较治疗前、后急性生理与慢性健康状况评分Ⅱ,观察治疗后28d生存率。结果血浆透析滤过治疗后患者血肌酐[(281.9±47.1)μmol/L]、白细胞介素-6[(109.6±23.9)μg/L]、尿素氮[(18.7±2.9)mmol/L]、胱抑素C[(2.8±0.7)mg/L]水平低于治疗前[(496.8±51.5)μmol/L、(287.5±49.7)μg/L、(27.8±4.5)mmol/L、(4.7±1.1)mg/L](P<0.05),急性生理与慢性健康状况评分Ⅱ(20.8±9.5)与治疗前(29.9±8.1)比较差异无统计学意义(P>0.05);血浆透析滤过治疗后28d生存率为66.7%。结论血浆透析滤过可有效改善全身炎症反应综合征诱发的急性肾损伤。
Objective To investigate the efficacy and safety of hemodiafiltration in the treatment of acute renal injury induced by systemic inflammatory response syndrome. Methods Fifteen patients with acute renal injury induced by systemic inflammatory response syndrome were treated with hemodiafiltration, and the renal function, serum interleukin-6 and cystatin C levels were measured before and after treatment. Acute physiology And chronic health status score Ⅱ, the survival rate after 28 days was observed. Results Serum creatinine [(281.9 ± 47.1) μmol / L], IL-6 [(109.6 ± 23.9) μg / L] and urea nitrogen [(18.7 ± 2.9) mmol / L] The level of cystatin C was significantly lower than that before treatment [(496.8 ± 51.5) μmol / L, (287.5 ± 49.7) μg / L, (27.8 ± 4.5) mmol / L, 1.1) mg / L] (P <0.05). There was no significant difference between acute physiology and chronic health status score Ⅱ (20.8 ± 9.5) and before treatment (29.9 ± 8.1) The survival rate after 28 days was 66.7%. Conclusion Hemodialysis filtration can effectively improve acute renal injury induced by systemic inflammatory response syndrome.