目的研究褐藻胶对大鼠实验性肝纤维化的防治作用．方法用４０％四氯化碳（ＣＣｌ４）制备大鼠肝纤维化模型，实验分组为正常对照组（ｎ＝８），ＣＣｌ４组（ｎ＝８），秋水仙硷（ＣＯＬ）组（ｎ＝６）和褐藻胶组（ｎ＝６）（２００ｍｇ／ｋｇ，ｉｇ，３次／周×４）．观察肝脏组织学和血清Ⅲ型前胶原（ＰＣⅢ）及透明质酸（ＨＡ）水平的变化．结果褐藻胶组ＰＣⅢ（１４２８μｇ／Ｌ±７６１μｇ／Ｌ）和ＨＡ水平（２６５５μｇ／Ｌ±９３１μｇ／Ｌ）显著低于ＣＣｌ４组（２９３５μｇ／Ｌ±７８３μｇ／Ｌ，５１９８μｇ／Ｌ±１１８３μｇ／Ｌ，Ｐ＜００１），而褐藻胶组与ＣＯＬ组间无显著差异．病理学观察显示，ＣＣｌ４组肝纤维化程度重于褐藻胶组和ＣＯＬ组．结论褐藻胶对实验性肝纤维化有防治作用． Objective To study the preventive and therapeutic effects of alginate on experimental hepatic fibrosis in rats. Methods The rat model of hepatic fibrosis was established by using 40% carbon tetrachloride (CCl4). The experimental group was divided into normal control group (n = 8), CCl4 group (n = 8), colchicine group ) And alginate group (n = 6) (200 mg / kg, ig, 3 times / week × 4). The changes of liver histology and serum levels of type Ⅲ procollagen (PC Ⅲ) and hyaluronic acid (HA) were observed. Results The levels of PCⅢ (1428 μg / L ± 761 μg / L) and HA (2655 μg / L ± 931 μg / L) in alginate group were significantly lower than those in CCl 4 group (2935 μg / L ± 783 μg / L, 5198 μg / L ± 1183 μg / L, P <001), while there was no significant difference between alginate group and COL group. Pathological observation showed that the degree of hepatic fibrosis in CCl4 group was heavier than that in alginate group and COL group. Conclusion Alginate has preventive and therapeutic effects on experimental liver fibrosis.