本文报告53例正常妊娠血清、100例羊水、44例脐带血的甲胎蛋白(AFP)测定和4例畸形胎儿羊水 AFP 测定结果。表明:正常母血 AFP 在妊娠3个月末开始出现,至27～30周达高峰,34周始下降,40周达最低值;羊水中 AFP值16周后达高峰,20周开始下降,足月降至最低值;脐带血中 AFP 仅能代表新生儿水平。无脑畸形、脑脊膜膨出病例羊水中 AFP 呈明显高值。初步认为,测定妊娠母血及羊水中 AFP 对予测某些胎儿畸形具有辅助诊断价值。 This paper reports 53 cases of normal pregnancy serum, 100 cases of amniotic fluid, 44 cases of cord blood AFP (AFP) determination and 4 cases of abnormal fetal amniotic fluid AFP determination results. The results showed that normal maternal blood AFP began to appear at the end of 3 months of gestation, peaked at 27-30 weeks, decreased at 34 weeks and reached the lowest level at 40 weeks. AFP in amniotic fluid peaked at 16 weeks and began to decline at 20 weeks, The lowest; cord blood AFP can only represent the level of newborns. Anemia, meningococcal meningitis in cases of amniotic fluid was significantly higher. Preliminary thought that the determination of gestational maternal blood and amniotic fluid AFP in the diagnosis of some fetal malformations have diagnostic value.