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诺氟沙星(Norfloxacin)属新一代喹诺酮类抗生素,据文献报道,它能干扰微生物DNA 螺旋酶活性,对细胞有高度渗透作用,与其它抗菌药物之间无交叉耐药性,不易产生耐药菌株。1985年国内已开始产生口服剂,主要用于肠道和泌尿道感染具有抗菌谱广,抗菌力强等特点。诺氟沙星眼用剂型,1989年在日本市场上已有出售,而国内尚无国产商品上市,为填补我国的空白,我院眼科从1989年8月10日至1990年8月1日参加诺氟沙星滴眼液的部分临床验证工作,现将一组随机双盲临床研究结果报道如下。
Norfloxacin is a new generation of quinolone antibiotics. It has been reported in the literature that it can interfere with microbial DNA gyrase activity, has a high degree of permeability to cells, has no cross-resistance with other antibacterial drugs and is not easily drug-resistant Strain. In 1985 the country has begun to produce oral agents, mainly for intestinal and urinary tract infections with broad antibacterial spectrum, strong antibacterial characteristics. Norfloxacin ophthalmic dosage form, 1989 has been sold in the Japanese market, but there is no domestic product listing, in order to fill the gaps in our hospital ophthalmology from August 10, 1989 to August 1, 1990 to participate Norfloxacin eye drops part of the clinical validation work, now a group of randomized double-blind clinical study results are reported below.