胆固醇逆向转运是周围细胞胆固醇转运至肝脏转化、清除的重要生理过程。研究证实 ,胆固醇逆向转运实际上是高密度脂蛋白在多种生物活性分子参与下 ,由新生前 β 高密度脂蛋白到成熟α 高密度脂蛋白递变的过程。过氧化体增殖物激活型受体α是一种核内受体转录因子 ,具有多种生物学效应 ,其激活后可影响决定高密度脂蛋白结构和功能的基因表达 ,从而调节胆固醇逆向转运过程。 Reverse cholesterol transport is the surrounding cellular cholesterol transport to the liver, an important physiological process of clearance. Studies have confirmed that reverse cholesterol transport is actually HDL in a variety of bioactive molecules involved, from pre-β-HDL to mature α-HDL process. Peroxisome proliferator-activated receptor alpha is a nuclear receptor transcription factor that has a variety of biological effects that, upon activation, affect the expression of genes that determine the structure and function of HDL and thereby regulate the cholesterol reverse transport process .