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目的 :研究凋亡相关蛋白Fas、Fas_L和Bcl_2在胃癌中的表达及其意义。方法 :应用免疫组化S_P法对 10例正常胃粘膜、 6 6例胃癌及 2 8例癌旁组织进行检测。结果 :①Fas、Fas_L和Bcl_2在胃癌中表达的阳性率分别为 5 7 5 8%、 5 0 0 0 %和5 1 5 1% ;在癌旁为 80 14%、 5 3 33%和 2 8 5 7% ;在正常胃粘膜中为 10 0 %、 0 %和 0 % ;②Fas表达在Ⅰ、Ⅱ期组明显高于Ⅲ、Ⅳ期组 ,在无淋巴结转移组明显高于有淋巴结转移组 ;③Fas_L和Bcl_2在肠型胃癌中的表达明显高于弥漫型胃癌 ;④肿瘤周围浸润的淋巴细胞有明显的Fas及Fas_L表达。结论 :Fas的下调表达及Fas_L的上调表达在胃癌的发生发展中起重要作用 ,Fas_L和Bcl_2在肠型胃癌的发病机制中发挥重要的作用 ,Fas的表达对估计病人的预后有一定的价值
Objective: To study the expression and significance of apoptosis-related proteins Fas, Fas_L and Bcl_2 in gastric cancer. Methods: Immunohistochemical S_P method was used to detect 10 cases of normal gastric mucosa, 66 cases of gastric cancer and 28 cases of adjacent tissues. RESULTS: 1 The positive rates of Fas, Fas_L and Bcl_2 expression in gastric cancer were 5 7 5 8%, 5 0 0 % and 5 1 5 1%, respectively; in cancer adjacent to 80 14%, 53 3 33% and 285 7%; in the normal gastric mucosa was 100%, 0% and 0%; 2Fas expression in the I, II group was significantly higher than the III, IV group, in the group without lymph node metastasis was significantly higher than the group with lymph node metastasis; 3Fas_L The expression of Bcl_2 in intestinal type gastric cancer was significantly higher than that of diffuse type gastric cancer. 4 The lymphocytes infiltrating around the tumor showed significant expression of Fas and Fas_L. Conclusion: Down-regulation of Fas and up-regulation of Fas_L play an important role in the development of gastric cancer. Fas_L and Bcl_2 play an important role in the pathogenesis of intestinal-type gastric cancer. Fas expression has a certain value in estimating the prognosis of patients.