罗马La Sapienza大学卫生研究所设立的狂犬病中心具有100年狂犬病接触后免疫接种经验,他们在日常工作中发现,50岁以上的老年人接种狂犬病疫苗后产生的中和抗体滴度比年轻人低,因此,本文作者进一步观察了不同年龄组人群对现行狂犬病疫苗的免疫应答情况。 试验采用两种疫苗,纯化的鸭胚狂犬病疫苗（PDEV）人二倍体细胞狂犬病疫苗（HDCV）。两种疫苗均采用狂犬病病毒Pit-man-Moore株,均用β丙内酯灭活。每剂疫苗的抗原值应≥2.5IU（NIH法）。 260名受试对象的年龄为11～25岁或50岁以上。均未接种过狂犬病疫苗。免疫程序为0、3、7、14、30和90天。最终共有204人完成全程免疫,其中11～25岁者111人;50岁以上者93人。分别在接种疫苗前（T_0）、接种第5针疫苗前（T_1）以及接种第6针疫苗前（T_2）采血,用改良的间接荧光抗体微量试验检测抗狂犬病抗体。另外,要求受试者在疫苗接种期间记录接种部位和全身反应情况。 结果表明,两种疫苗均能很好耐受。107名HDCV接种者中仅1人出现乏力,2人有接种部位疼痛。97名接种PDEV者中有4人出 The rabies center set up by the Institute of Health at the University of La Sapienza in Rome has 100 years of post-immunization exposure to rabies and found that neutralizing antibodies in rabies vaccines are lower in older people over 50 than in young people, Therefore, the author of this paper further observed the different age groups of people on the current rabies vaccine immune response. Two vaccines, a purified duck embryo rabies vaccine (PDEV) human diploid rabies vaccine (HDCV) were used. Both vaccines use the rabies virus Pit-man-Moore strain, both inactivated with beta propiolactone. The antigen value per dose should be ≥ 2.5IU (NIH method). 260 subjects were 11 to 25 years old or over 50 years of age. Did not inoculate rabies vaccine. Immune procedures were 0, 3, 7, 14, 30 and 90 days. A total of 204 people completed the whole immune system, of which 11 to 25-year-old 111; 93 people over the age of 50. Blood samples were taken before T5 vaccination, before T5 vaccination and before T6 vaccination, and anti-rabies antibody was detected by modified indirect fluorescent antibody micro assay. In addition, subjects are required to record the site of vaccination and systemic response during vaccination. The results show that both vaccines are well tolerated. Only one out of 107 HDCV vaccines developed fatigue and two had pain at the site of vaccination. Four out of 97 inoculated PDEV were out