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近年来,纳米材料凭借其独特的光、声、电、磁、热和力学特性在生物医学领域中得到广泛应用,也为卵巢癌的早期诊断、精确分期和肿瘤病灶的定位带来福音。在卵巢癌细胞分离中,修饰靶向分子后的磁性纳米材料能特异性地捕获卵巢癌细胞,并在外加磁场作用下将其分离,为卵巢癌患者体内扩散的癌细胞的检测和清除提供了技术手段;在卵巢癌检测技术中,纳米材料制成的生物传感器能够有效提高卵巢癌患者样本分析的效率、选择性及特异性;纳米材料制成的造影剂不仅能同时适用于多种成像技术,还可以提高其对卵巢癌组织的成像灵敏度与分辨率,实现卵巢癌的分子成像;纳米材料与质谱分析结合后,可有效提高其检测的灵敏度,在卵巢癌的蛋白组学分析中发挥更好的作用。
In recent years, nanomaterials have been widely used in the field of biomedicine because of their unique optical, acoustic, electrical, magnetic, thermal and mechanical properties. They also bring good news for the early diagnosis of ovarian cancer, accurate staging and the localization of tumor lesions. In the separation of ovarian cancer cells, the magnetic nanomaterials modified by targeting molecules can specifically capture ovarian cancer cells and separate them under the action of an external magnetic field, thereby providing detection and clearance of the spread of cancer cells in ovarian cancer patients Technology; in ovarian cancer detection technology, biosensors made of nanomaterials can effectively improve the efficiency, selectivity and specificity of sample analysis for patients with ovarian cancer; contrast agents made of nanomaterials can not only be applied to a variety of imaging techniques , But also can improve the imaging sensitivity and resolution of ovarian cancer tissue and realize the molecular imaging of ovarian cancer. The combination of nanomaterials and mass spectrometry can effectively improve the sensitivity of detection and play a more important role in proteomic analysis of ovarian cancer Good effect.