两种速效胰岛素类似物(赖脯胰岛素、天冬胰岛素),由于改变了胰岛素分子间相互作用的重要区域,其起效、达到峰值、作用持续时间均较常规人胰岛素短,对迅速降低餐后血糖、减少下一餐前低血糖优于常规人胰岛素。而两种长效胰岛素类似物(甘精胰岛素、地特胰岛素)通过改变胰岛素的等电点或增加类似物分子量的方法,使其分解、吸收及作用时间延长,吸收变异度小,而且无峰值,能更好地模拟生理基础胰岛素分泌。 Two fast-acting insulin analogs, insulin lispro and aspirin, peak in effect by changing important regions of insulin-molecule interactions and have a shorter duration of action than conventional human insulin, Blood sugar, reducing hypoglycemia before the next meal is superior to regular human insulin. The two long-acting insulin analogs (glargine, detemir insulin) by changing the isoelectric point of insulin or increasing the molecular weight of analogs, so that its decomposition, absorption and prolongation of the role of small changes in absorption, and no peak , Can better simulate physiological basal insulin secretion.