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目的:探讨博利康尼联合氨溴索雾化吸入治疗毛细支气管炎的治疗效果。方法:120例毛细支气管炎患儿随机分为治疗组(A、B、C组)与对照组各30例。A组:博利康尼雾化液2.5 mg/次;B组:氨溴索注射液7.5 mg/次;C组:博利康尼雾化液2.5 mg/次及氨溴索注射液7.5 mg/次;对照组:α-糜蛋白酶5 mg/次。每组药物均加入生理盐水5 mL稀释以空气压缩泵雾化吸入,2次/d,5~10 min/次,连用5~7 d。观察各组咳嗽、喘憋、气促、哮鸣音和湿口罗音好转情况及不良反应。结果:总有效率C组与A组、B组、对照组三组比较差异均有统计学意义(χ2=5.19,4.04,7.21,P均<0.05)。A组、B组、对照组三组间比较差异无统计学意义(χ2=0.37,P>0.05)。喘憋消失、气促缓解、哮鸣音消失、湿口罗音消失及平均住院时间C组与A组、B组、对照组三组比较明显缩短,差异均有统计学意义(P均<0.05)。结论:博利康尼联合氨溴索雾化吸入治疗毛细支气管炎能增强疗效,缓解症状,缩短病程,提高治愈率,安全、有效、简便。
OBJECTIVE: To investigate the therapeutic effect of bleomycin combined with inhalation of ambroxol on bronchiolitis. Methods: A total of 120 children with bronchiolitis were randomly divided into treatment group (A, B and C) and control group (30 cases each). Group B: 2.5 mg Boli Kang Ni aerosol; Group B: Ambroxol injection 7.5 mg / C; Group B: 2.5 mg Boli Kang Ni aerosol and ambroxol injection 7.5 mg / time ; Control group: α-chymotrypsin 5 mg / time. Each group of drugs were added 5 mL of normal saline diluted with air compression pump atomized inhalation, 2 times / d, 5 ~ 10 min / times, once every 5 ~ 7 d. Observe the cough, wheezing, shortness of breath, wheeze and wet mouth rales improved and adverse reactions in each group. Results: The total effective rate of group C was significantly different from that of group A, group B and control group (χ2 = 5.19,4.04,7.21, P <0.05). There was no significant difference among the three groups in group A, group B and control group (χ2 = 0.37, P> 0.05). Wheezing disappeared, relief of shortness of breath, disappearance of wheeze, disappearance of wet mouth rales and average length of stay in group C were significantly shorter than those in group A, group B and control group (all P <0.05 ). Conclusion: The treatment of bronchiolitis by inhalation of combination of ambroxol and ambroxol can enhance the curative effect, alleviate the symptoms, shorten the course of disease and improve the cure rate. It is safe, effective and simple.