论文部分内容阅读
There is an urgent and tremendous need for human disease models in drug development in order to improve preclinical predictability.In the case of brain disorders drugs have to cross the blood-brain barrier(BBB)to enter the central nervous system(CNS).It was estimated that more than 95%of the drugs cannot cross the BBB.In the case of biopharmaceutics,it seems to be even more difficult for
There is an urgent and tremendous need for human disease models in drug development in order to improve preclinical predictability.In the case of brain disorders drugs have to cross the blood-brain barrier (BBB) to enter the central nervous system (CNS) .It was estimated that more than 95% of the drugs can not cross the BBB.In the case of biopharmaceutics, it seems to be even more more difficult for