论文部分内容阅读
从1933年Zimmerman介绍了作为支持肾小球毛细血管结构的肾小球系膜以来,直到早期电镜应用于肾脏研究才被证实,并命名为毛细血管轴索(axial),毛细血管间质(intcrcapillary),或毛细血管小叶中央区(Centrolobular)。但由于早期电镜的分辨率低,所以仍不能区分出系膜细胞。随着电镜技术的进展,到60年代初,Latta和Farquhar等才指出了系膜细胞作为肾小球第三型细胞存在的证据,并描述了系膜细胞的形态,指出了系膜细胞与内皮细胞的区别在于,①系膜细胞有很多不规则的胞浆性突起;②胞浆不如内皮细胞致密;③核的形态比内皮细胞规则;④可见胞浆性颗粒成分;⑤可见细胞膜下与平滑肌细胞相似的附着体(attachment body),并有束状肌丝与之相连;⑥可见胶原束的形成。从这以后,特别
Since 1933 Zimmerman introduced mesangial mesangial cells that support the glomerular capillary architecture, it has not been demonstrated until early TEM studies in kidney studies and was named capillary axial, ), Or Centrolobular. However, due to the low resolution of the early electron microscope, it still can not distinguish between mesangial cells. With the progress of electron microscopy, by the early 1960s, Latta and Farquhar pointed out the existence of mesangial cells as glomerular type III cells and described the morphology of mesangial cells, noting that mesangial cells and endothelium The difference between cells is that ① mesangial cells have many irregular cytoplasmic protrusions; ② cytoplasm less dense than endothelial cells; ③ nuclear morphology than the rules of endothelial cells; ④ visible cytoplasmic granular components; ⑤ can be seen under the cell membrane and smooth muscle Cells similar attachment body (attachment body), and a bundle of myofilament attached; ⑥ collagen bundles can be seen the formation. From now on, special