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最近20年来的研究发现炎症介质(如前列腺素(PG)、白三烯(LT)、5-羟甘碳四烯酸(5-HETE)和5-氢过氧化廿碳四烯酸(HPETE)、5-羟色胺(5-HT)P物质及缓激肽等是一类致泻性自体活性物质,无论在非感染性腹泻(如炎性肠病、多种肿瘤性腹泻、倾泻综合征、肠易激综合征和放射性炎肠炎等),还是感染性腹泻(如内毒素、霍乱毒素等)中、腹泻症状的发生与炎症介质的合成释放有关。而抗炎药物抗腹泻作用研究也因此取得了很大进展。 1非甾体抗炎药(NSAID) 包括酸性NSAID(即环氧化酶抑制剂、包括乙酰水杨酸(阿斯匹林)、吲哚美辛、保泰松、灭酸类和苯丙酸类等)及非酸性NSAID(几乎不抑制环氧化
Recent studies from 20 years have found that inflammatory mediators such as prostaglandin (PG), leukotriene (LT), 5-HETE and HPETE, , Serotonin (5-HT) substance P and bradykinin are a class of diarrheal auto-active substances, both in non-infectious diarrhea (such as inflammatory bowel disease, multiple tumor diarrhea, Irritable syndrome and radiation inflammation, etc.), or infectious diarrhea (such as endotoxin, cholera toxin, etc.), the occurrence of diarrhea and inflammatory mediators related to the synthesis and release of anti-inflammatory drugs and anti-diarrhea effect of the study has been made 1 Nonsteroidal anti-inflammatory drugs (NSAIDs) include acidic NSAIDs (ie, cyclooxygenase inhibitors including aspirin, indomethacin, phenylbutazone, fenamic acid And phenylpropionic acids, etc.) and non-acidic NSAIDs (with little inhibition of epoxidation