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目的:研究单核细胞趋化蛋白-1(MCP-1)在类风湿关节炎(RA)发病中的作用,探讨其与RA继发间质性肺疾病(ILD)的关系及其可能的临床价值。方法:选择RA患者60例,按是否存在ILD,分为单纯RA组30例和RA继发ILD组30例,正常对照组20例,应用ELISA测定各组血清MCP-1水平,比较各组MCP-1水平的差异,同时比较各组中实验室指标IgG、IgA、IgM、α2-球蛋白、γ-球蛋白、RF、ESR、CRP及关节肿痛数的差异,并分析以上指标与血清MCP-1表达的相关性。结果:RA患者MCP-1的表达明显高于健康对照组,RA继发ILD组显著高于单纯RA组。RA患者血清MCP-1与IgG、IgM、γ-球蛋白均呈正相关。结论:MCP-1是RA发病中重要的细胞因子,在RA继发ILD过程中可能起着一定的促进作用。
AIM: To investigate the role of monocyte chemoattractant protein-1 (MCP-1) in the pathogenesis of rheumatoid arthritis (RA) and its relationship with secondary interstitial lung disease (ILD) and its possible clinical value. Methods: Sixty patients with RA were divided into two groups according to the presence or absence of ILD: 30 patients in RA group and 30 patients in RA secondary ILD group, and 20 patients in normal control group. Serum MCP-1 levels were measured by ELISA. -1, and the difference of laboratory indexes IgG, IgA, IgM, α2-globulin, γ-globin, RF, ESR, CRP and joint swelling and pain were compared between the groups. -1 expression of the correlation. Results: The expression of MCP-1 in RA patients was significantly higher than that in healthy controls. The levels of MCP-1 in RA patients were significantly higher than those in RA patients. The serum level of MCP-1 in RA patients was positively correlated with IgG, IgM and γ-globulin. CONCLUSION: MCP-1 is an important cytokine in the pathogenesis of RA and may play a role in promoting ILD secondary to RA.