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目的探讨胃和小肠胃肠道间质瘤(GIST)患者临床病理特征的差异性。方法经手术治疗的GIST患者164例,其中男75例,女89例,年龄50—70岁。比较胃及小肠GIST的临床病理特点。结果肿瘤最常发生于胃(127例),其次为小肠(27例);肿瘤已出现肝或腹腔转移6例,淋巴结转移1例,伴发胃肠道恶性肿瘤或癌前病变8例。复发风险极低度47例,低度50例,中度24例,高度37例。胃和小肠各组的肿瘤大小、肿瘤出血、坏死、CD34表达阳性率比较,差异有统计学意义(P<0.05)。结论胃及小肠GIST的首发症状、肿瘤大小、CD34阳性率以及坏死出血概率有差异。
Objective To investigate the difference of clinicopathological features between gastrointestinal stromal tumors (GIST) and gastric and small intestine. Methods 164 cases of GIST treated by surgery, including 75 males and 89 females, aged 50-70 years. Comparison of gastric and intestinal GIST clinical and pathological features. Results Tumor occurred most frequently in the stomach (127 cases), followed by the small intestine (27 cases). There were 6 cases of liver or peritoneal metastasis, 1 case of lymph node metastasis, 8 cases of gastrointestinal cancer or precancerous lesions. Forty-seven patients were at very low risk of recurrence, with a low degree of 50, a moderate degree of 24, and a height of 37. The tumor size, tumor hemorrhage, necrosis and the positive rate of CD34 expression in stomach and small intestine were significantly different (P <0.05). Conclusion The initial symptoms of GIST in stomach and small intestine, tumor size, positive rate of CD34, and the probability of necrotic hemorrhage are different.