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目的:了解周口市0～3岁小儿佝偻病患病情况,分析25(OH)D3与骨碱性磷酸酶(BALP)在佝偻病诊断中的价值。方法:抽取周口市0～3岁小儿样本240例,采用问卷调查方法对小儿营养状况、既往病史、饮食习惯、生活环境、户外活动等情况进行调查,并测定小儿身高、体重、血清钙、磷、25(OH)D3和BALP水平。结果:240例小儿中患佝偻病25例,患病率为10.42%,其中0～6个月龄患病率最高为20.97%,明显高于其他年龄段患病率(P<0.05)。佝偻病患病率与小儿喂养方式、居住环境、饮食习惯、户外活动和反复呼吸道感染有关,差异有统计学意义(P<0.01)。佝偻病患儿血清25(OH)D3和BALP水平明显低于非佝偻病小儿(P<0.01)。结论:0～6个月龄是小儿佝偻病高发段,儿童佝偻病患病与喂养方式、居住环境、饮食习惯、户外活动和反复呼吸道感染有关,其血清25(OH)D3和BALP明显低于健康儿童。
Objective: To investigate the prevalence of rickets in children aged 0-3 years in Zhoukou City and to analyze the value of 25 (OH) D3 and bone alkaline phosphatase (BALP) in the diagnosis of rickets. Methods: A total of 240 children aged 0-3 years were collected from Zhoukou City. The nutritional status, past medical history, eating habits, living environment and outdoor activities were investigated by questionnaire. The children’s height, weight, serum calcium and phosphorus , 25 (OH) D3 and BALP levels. Results: Among 240 children, 25 cases were suffering from rickets, with a prevalence of 10.42%. The highest prevalence rate of 0-6 months was 20.97%, which was significantly higher than other age groups (P <0.05). The prevalence of rickets was related to pediatric feeding style, living environment, eating habits, outdoor activities and recurrent respiratory tract infections, the difference was statistically significant (P <0.01). The serum levels of 25 (OH) D3 and BALP in children with rickets were significantly lower than those in non-rickets children (P <0.01). Conclusion: 0 to 6 months old children with rickets high incidence of children with rickets and feeding patterns, living environment, eating habits, outdoor activities and recurrent respiratory tract infections, serum 25 (OH) D3 and BALP was significantly lower than healthy children .